The vitamin D receptor is found in bone, most tissues and cells in the body. In addition, cholecalciferol (800 IU/d) significantly increased the serum 25(OH)D concentration.

We concluded that both cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) plus Caltrate D modifies the serum calcium and bone turnover markers in Chinese postmenopausal women with vitamin D insufficiency. The levels of serum intact parathyroid hormone in both the groups were significantly decreased (group A: from 48.56☑2.8 to 39.59☑2.6 pg/mL group B: from 53.67☒0.0 to 40.32☑5.4 pg/mL).

The serum calcium levels in both the groups were significantly increased (group A: from 2.36☐.1 to 2.45☐.1 mmol/L group B: from 2.36☐.1 to 2.44☐.1 mmol/L). Results:Īfter the 3-month intervention, the serum 25(OH)D concentration in group A was significantly increased from 16.01±5.0 to 20.02±4.5 ng/mL, while that in group B had no significant change.

The markers of calcium metabolism and bone turnover, including the serum levels of calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25(OH)D and β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX), were measured before and after the intervention. In addition, all the subjects received Caltrate D (calcium plus 125 IU cholecalciferol) daily in the form of one pill. The subjects were divided into 2 groups based on the age and serum 25(OH)D concentration: 50 subjects (group A) received cholecalciferol (800 IU/d), and 50 subjects (group B) received calcitriol (0.25 μg/d) for 3 months. One hundred Chinese postmenopausal women aged 63.8☗.0 years and with serum 25-hydroxyvitamin D concentration <30 ng/mL were recruited. To compare the effects of cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency.

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